Methods Find Exp Clin Pharmacol. 2006 Apr;28(3):169-75.
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Diabetes, insulin, and risk of cancer.
Schiel R, Beltschikow W, Steiner T, Stein G.
Department of Diabetes and Metabolic Diseases, Inselklinik Heringsdorf GmbH,
Seeheilbad Heringsdorf, University of Jena Medical School, Jena, Germany. i
[email protected]
Up to now, the studies involving diabetes mellitus and malignancies show con
troversial results: Many of them have found incidences of malignancies that
were comparable or even lower than those in nondiabetic subjects; others con
clude that diabetes mellitus is linked to a higher incidence of malignancies
and/or a predictor of mortality from cancer. Insulin and its precursors, pr
o- and pre-proinsulin, have been shown to have some homology to the insulin-
like growth factors, but, moreover they have some affinity to bind at recept
ors of the tumor growth factor and some hybrids too. Hence, an association b
etween diabetes mellitus, insulin, hyperinsulinaemia, and carcinogenesis app
ears plausible. On the other hand, diabetes mellitus can influence different
hormone levels. In some tumor entities, such as prostate carcinoma, this ef
fect can somewhat counterbalance the direct mitogene effect of insulin and i
ts precursors. All in all, as a result of the complexity of these mechanisms
and the differences between the tumor entities, the question whether diabet
es mellitus is associated with an increased or a reduced risk for the develo
pment and in respect of the prognosis of cancer cannot be answered. The only
way to give some answer is to focus on specific tumor entities: It seems th
at diabetes mellitus and/or hyperglycaemia are independent risk factors and/
or predictors at least in respect of cancer of the colon, pancreas, female b
reast, endometrium, and, in men, of the liver and bladder. However, most of
these data were assessed in patients with type 2 diabetes mellitus.
乎表明，糖尿病和/或高血糖是某些疾病不稳定的危险和/或预测因素，如结肠、胰腺、
女性的乳腺、子宫内膜和男性的肝脏、膀胱肿瘤。然而大多数出具是从2型糖尿病得出的
。
This makes it highly questionable whether the data can easily be transferred
to patients with type 1 diabetes. Moreover, additional potential limitation
s are that most of the studies do not focus on the treatment modality or the
race of participants. In conclusion, up to the present, we have an increase
d risk for some and a reduced risk for other tumor entities, but still, we c
annot give the general answer. Copyright 2006 Prous Science
但是，目前我们仍不能给出一个总体的答案。
PMID: 16810343 [PubMed - indexed for MEDLINE]
糖尿病增加患癌的风险？
